Subject(s)
COVID-19/complications , Hematoma/virology , Placenta Diseases/virology , Pregnancy Complications, Infectious/virology , Thrombosis/virology , COVID-19/virology , Female , Hematoma/pathology , Humans , Male , Placenta Diseases/pathology , Pregnancy , Pregnancy Complications, Infectious/pathology , Retrospective Studies , SARS-CoV-2 , Stillbirth , Thrombosis/pathologyABSTRACT
Neurovascular involvement is a frequent occurring reported in COVID-19 patients. However, spontaneous hematomas of the corpus callosum are exceptionally seen. The authors of this article aim to report an unusual case of corpus callosum hematoma in a COVID-19 patient and discuss potential etiologies and mechanisms responsible for intracranial hemorrhage.
Subject(s)
COVID-19/complications , Corpus Callosum/pathology , Hematoma/diagnosis , Intracranial Hemorrhages/diagnosis , Corpus Callosum/virology , Hematoma/etiology , Hematoma/virology , Humans , Intracranial Hemorrhages/etiology , Intracranial Hemorrhages/virology , Male , Middle AgedABSTRACT
Hemorrhagic manifestations during COVID-19 infections are increasingly described in the literature. We report the first case of spontaneous subcapsular hematoma of the liver revealing a COVID-19 infection in a 44-year-old woman with no underlying health condition history, a computerized tomography evaluation showed an aspect of lung ground-glass opacities, with moderate impairment estimated at about 20%. Reverse transcription-polymerase chain reaction confirmed the diagnosis of COVID-19 infection. During the COVID-19 pandemic, non-traumatic bleeding such as spontaneous hematomas in patients with no coagulation disorder could be a manifestation of COVID-19 infection.
Subject(s)
COVID-19/diagnosis , Hematoma/diagnosis , Liver Diseases/diagnosis , Adult , COVID-19/complications , Female , Hematoma/pathology , Hematoma/virology , Humans , Liver Diseases/pathology , Liver Diseases/virology , Reverse Transcriptase Polymerase Chain Reaction , Tomography, X-Ray ComputedABSTRACT
Anticoagulation plays a major role in reducing the risk of systematic thrombosis in patients with severe COVID-19. Serious hemorrhagic complications, such as intracranial hemorrhage, have also been recognized. However, intra-abdominal hemorrhage is under-recognized because of its rare occurrence, despite high mortality. Here, we discuss two cases of spontaneous iliopsoas hematoma (IPH) likely caused by anticoagulants during the clinical course of COVID-19. We also explored published case reports to identify clinical characteristics of IPH in COVID-19 patients. The use of anticoagulants may increase the risk of lethal IPH among COVID-19 patients becsuse of scarce data on optimal dosage and adequate monitoring of anticoagulant effects. Rapid diagnosis and timely intervention are crucial to ensure good patient outcomes.
Subject(s)
Abscess/virology , COVID-19/complications , Hematoma/diagnosis , Hematoma/virology , Muscle, Skeletal/pathology , Abscess/classification , Abscess/diagnosis , Aged , Anticoagulants/adverse effects , Antiviral Agents/therapeutic use , Blood Coagulation , COVID-19/diagnostic imaging , Fatal Outcome , Hematoma/classification , Hematoma/drug therapy , Humans , Male , Middle Aged , Muscle, Skeletal/virology , Severity of Illness Index , Thigh/pathology , Tomography, X-Ray Computed , Treatment Outcome , COVID-19 Drug TreatmentABSTRACT
BACKGROUND Pandemic coronavirus disease 2019 (COVID-19) originated in Wuhan, China, and is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Severe respiratory symptoms are a hallmark of the disease, which may also include complications related to a hypercoagulable state and central nervous system involvement. These complications can occur during either the acute or the recovery phase. The cerebral involvement typically manifests as intracranial hypertension, intracerebral hemorrhage, diffuse encephalopathy, or cerebral venous thrombosis. The hemorrhagic form of cerebral venous thrombosis can be a diagnostic challenge and is treated by anticoagulation therapy, despite the existence of an intracerebral hemorrhage. This report describes a case of superficial cerebral venous thrombosis and intracerebral hematoma in a 48-year-old man weeks after recovering from the acute phase of SARSCoV-2 infection. CASE REPORT A 48-year-old man with a past medical history of SARS-CoV-2 infection confirmed by SARS-CoV-2 reverse-transcription polymerase chain reaction presented with left upper-limb numbness, weakness, and impaired positional sensorium. After initial stabilization, noncontrast computerized tomography and magnetic resonance imaging confirmed an intracerebral hemorrhage with underlying cerebral venous thrombosis. The patient was successfully treated with enoxaparin anticoagulation therapy, and symptoms improved over the following 12 days. CONCLUSIONS Central nervous system venous thrombosis is an atypical presentation of the hypercoagulable state primarily seen in younger patients, and it can occur in a delayed fashion after recovery from mild forms of COVID-19.
Subject(s)
COVID-19/complications , Cerebral Hemorrhage/diagnostic imaging , Hematoma/diagnostic imaging , Intracranial Thrombosis/diagnostic imaging , Venous Thrombosis/diagnostic imaging , Anticoagulants/therapeutic use , Cerebral Hemorrhage/virology , Enoxaparin/therapeutic use , Hematoma/virology , Humans , Intracranial Thrombosis/drug therapy , Intracranial Thrombosis/virology , Magnetic Resonance Imaging , Male , Middle Aged , Tomography, X-Ray Computed , Venous Thrombosis/drug therapy , Venous Thrombosis/virologyABSTRACT
Patients with durable left ventricular assist devices pose special problems for management in the setting of COVID-19 infection. We describe the successful management of a 44-year-old man with severe COVID-19 infection and HeartMate 3 left ventricular assist device. His course was complicated by cytokine storm and COVID-19-associated coagulopathy. We describe our institutional protocol for managing COVID-19 infection in patients on mechanical circulatory support, focusing on the need for a thoughtful, multidisciplinary approach.